Diabesity - novel molecular targets for obesity and type 2 diabetes

Publications 2007
The following publications have arisen from DIABESITY in 2007:

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
IS Farooqi, T Wangensteen, S Collins, W Kimber, G Matarese, JM Keogh, E Lank, B Bottomley, J Lopez-Fernandez, I Ferraz-Amaro, MT Dattani, O Ercan, AG Myhre, L Retterstol, R Stanhope, JA Edge, S McKenzie, N Lessan, M Ghodsi, V De Rosa, F Perna, S Fontana, I Barroso, DE Undlien and S O'Rahilly
N Engl J Med (2007) 356:237-247

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
T Gerken, CA Girard, YC Tung, CJ Webby, V Saudek, KS Hewitson, GS Yeo, MA McDonough, S Cunliffe, LA McNeill, J Galvanovskis, P Rorsman, P Robins, X Prieur, AP Coll, M Ma, Z Jovanovic, IS Farooqi, B Sedgwick, I Barroso, T Lindahl, CP Ponting, FM Ashcroft, S O'Rahilly and CJ Schofield
Science (2007) 318:1469-1472

Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
R Christensen, PK Kristensen, EM Bartels, H Bliddal and A Astrup
Lancet (2007) 370:1706-1713

Common variants in WFS1 confer risk of type 2 diabetes
MS Sandhu, MN Weedon, KA Fawcett, J Wasson, SL Debenham, A Daly, H Lango, TM Frayling, RJ Neumann, R Sherva, I Blech, PD Pharoah, CN Palmer, C Kimber, R Tavendale, AD Morris, MI McCarthy, M Walker, G Hitman, B Glaser, MA Permutt, AT Hattersley, NJ Wareham and I Barroso
Nat Genet (2007) 39:951-953

A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior
M Sakkou, P Wiedmer, K Anlag, A Hamm, E Seuntjens, L Ettwiller, MH Tschöp and M Treier
Cell Metab (2007) 5:450-463

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
AC Könner, R Janoschek, L Plum, SD Jordan, E Rother, X Ma, C Xu, P Enriori, B Hampel, GS Barsh, CR Kahn, MA Cowley, FM Ashcroft and JC Brüning
Cell Metab (2007) 5:438-449

The central melanocortin system directly controls peripheral lipid metabolism
R Nogueiras, P Wiedmer, D Perez-Tilve, C Veyrat-Durebex, JM Keogh, GM Sutton, PT Pfluger, TR Castaneda, S Neschen, SM Hofmann, PN Howles, DA Morgan, SC Benoit, I Szanto, B Schrott, A Schürmann, HG Joost, C Hammond, DY Hui, SC Woods, K Rahmouni, AA Butler, IS Farooqi, S O'Rahilly, F Rohner-Jeanrenaud and MH Tschöp
J Clin Invest (2007) 117:3475-3488

Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes
Y Emre, C Hurtaud, M Karaca, T Nubel, F Zavala and D Ricquier
Proc Natl Acad Sci U S A (2007) 104:19085-19090

Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes
K Tan, WA Kimber, J Luan, MA Soos, RK Semple, NJ Wareham, S O'Rahilly and I Barroso
Diabetes (2007) 56:714-719

Exendin-4 potently decreases ghrelin levels in fasting rats
D Pérez-Tilve, L González-Matias, M Alvarez-Crespo, R Leiras, S Tovar, C Diéguez and F Mallo
Diabetes (2007) 56:143-151

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies
JL Mesa, RJ Loos, PW Franks, KK Ong, J Luan, S O'Rahilly, NJ Wareham and I Barroso
Diabetes (2007) 56:884-889

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
RJ Loos, PW Franks, RW Francis, I Barroso, FM Gribble, DB Savage, KK Ong, S O'Rahilly and NJ Wareham
Diabetes (2007) 56:1943-1947

Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production
E Chevillotte, M Giralt, B Miroux, D Ricquier and F Villarroya
Diabetes (2007) 56:1042-1050

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
HN Lyon, V Emilsson, A Hinney, IM Heid, J Lasky-Su, X Zhu, G Thorleifsson, S Gunnarsdottir, GB Walters, U Thorsteinsdottir, A Kong, J Gulcher, TT Nguyen, A Scherag, A Pfeufer, T Meitinger, G Brönner, W Rief, ME Soto-Quiros, L Avila, B Klanderman, BA Raby, EK Silverman, ST Weiss, N Laird, X Ding, L Groop, T Tuomi, B Isomaa, K Bengtsson, JL Butler, RS Cooper, CS Fox, CJ O'Donnell, C Vollmert, JC Celedon, HE Wichmann, J Hebebrand, K Stefansson, C Lange and JN Hirschhorn
PLoS Genet (2007) 3:e61

Gonadotropin-releasing hormone neurons express estrogen receptor-beta
E Hrabovszky, I Kalló, N Szlávik, E Keller, I Merchenthaler and Z Liposits
J Clin Endocrinol Metab (2007) 92:2827-2830

Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
WS Dhillo, OB Chaudhri, EL Thompson, KG Murphy, M Patterson, R Ramachandran, GK Nijher, V Amber, A Kokkinos, M Donaldson, MA Ghatei and SR Bloom
J Clin Endocrinol Metab (2007) 92:3958-3966

The orphan nuclear receptor Rev-erbalpha: a transcriptional link between circadian rhythmicity and cardiometabolic disease
C Fontaine and B Staels
Curr Opin Lipidol (2007) 18:141-146

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
DJ O'Gorman, HK Karlsson, S McQuaid, O Yousif, Y Rahman, D Gasparro, S Glund, AV Chibalin, JR Zierath and JJ Nolan
Diabetologia (2006) 49:2983-2992

Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations
SC Collins, J Luan, AJ Thompson, A Daly, RK Semple, S O'Rahilly, NJ Wareham and I Barroso
Diabetologia (2007) 50:555-562

Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety
PS Singru, E Sánchez, C Fekete and RM Lechan
Endocrinology (2007) 148:638-646

Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. an ex vivo organ culture study
LM Seoane, O Al-Massadi, JE Caminos, SA Tovar, C Dieguez and FF Casanueva
Endocrinology (2007) 148:3998-4006

Effects of obestatin on energy balance and growth hormone secretion in rodents
R Nogueiras, P Pfluger, S Tovar, M Arnold, S Mitchell, A Morris, D Perez-Tilve, MJ Vázquez, P Wiedmer, TR Castañeda, R DiMarchi, M Tschöp, A Schurmann, HG Joost, LM Williams, W Langhans and C Diéguez
Endocrinology (2007) 148:21-26

Cocaine- and amphetamine-regulated transcript (CART) is colocalized with the orexigenic neuropeptide Y and agouti-related protein and absent from the anorexigenic alpha-melanocyte-stimulating hormone neurons in the infundibular nucleus of the human hypothalamus
J Menyhért, G Wittmann, RM Lechan, E Keller, Z Liposits and C Fekete
Endocrinology (2007) 148:4276-4281

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling
R Granata, F Settanni, L Biancone, L Trovato, R Nano, F Bertuzzi, S Destefanis, M Annunziata, M Martinetti, F Catapano, C Ghe, J Isgaard, M Papotti, E Ghigo and G Muccioli
Endocrinology (2007) 148:512-529

Contribution of noradrenergic and adrenergic cell groups of the brainstem and agouti-related protein-synthesizing neurons of the arcuate nucleus to neuropeptide-y innervation of corticotropin-releasing hormone neurons in hypothalamic paraventricular nucleus of the rat
T Füzesi, G Wittmann, Z Liposits, RM Lechan and C Fekete
Endocrinology (2007) 148:5442-5450

Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function
D Cota, MA Steiner, G Marsicano, C Cervino, JP Herman, Y Grübler, J Stalla, R Pasquali, B Lutz, GK Stalla and U Pagotto
Endocrinology (2007) 148:1574-1581

Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction
P Barrett, FJ Ebling, S Schuhler, D Wilson, AW Ross, A Warner, P Jethwa, A Boelen, TJ Visser, DM Ozanne, ZA Archer, JG Mercer and PJ Morgan
Endocrinology (2007) 148:3608-3617

Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
B Sloth, JJ Holst, A Flint, NT Gregersen and A Astrup
Am J Physiol Endocrinol Metab (2007) 292:E1062-1068

Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
B Sloth, L Davidsen, JJ Holst, A Flint and A Astrup
Am J Physiol Endocrinol Metab (2007) 293:E604-609

Maternal stress alters endocrine function of the feto-placental unit in rats
J Mairesse, J Lesage, C Breton, B Breant, T Hahn, M Darnaudéry, SL Dickson, J Seckl, B Blondeau, D Vieau, S Maccari and O Viltart
Am J Physiol Endocrinol Metab (2007) 292:E1526-1533

Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages
Y Emre, C Hurtaud, T Nübel, F Criscuolo, D Ricquier and AM Cassard-Doulcier
Biochem J (2007) 402:271-278

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of
29 563 individuals

EH Young, NJ Wareham, S Farooqi, A Hinney, J Hebebrand, A Scherag, S O'Rahilly, I Barroso and MS Sandhu
Int J Obes (Lond) (2007) 31:1437-1441

Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus
G Wittmann, L Deli, I Kalló, E Hrabovszky, M Watanabe, Z Liposits and C Fekete
J Comp Neurol (2007) 503:270-279

Hypothalamic neuropeptide gene expression during recovery from food restriction superimposed on short-day photoperiod-induced weight loss in the Siberian hamster
ZA Archer, KM Moar, TJ Logie, L Reilly, V Stevens, PJ Morgan and JG Mercer
Am J Physiol Regul Integr Comp Physiol (2007) 293:R1094-1101

Glutamatergic innervation of the hypothalamic median eminence and posterior pituitary of the rat
E Hrabovszky, L Deli, GF Turi, I Kallo and Z Liposits
Neuroscience (2007) 144:1383-1392

Peripheral tissue-brain interactions in the regulation of food intake
M López, S Tovar, MJ Vázquez, LM Williams and C Diáguez
Proc Nutr Soc (2007) 66:131-155

UCP2 is a mitochondrial transporter with an unusual very short half-life
S Rousset, J Mozo, G Dujardin, Y Emre, S Masscheleyn, D Ricquier and AM Cassard-Doulcier
FEBS Lett (2007) 581:479-482

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
Z Michailidou, AP Coll, CJ Kenyon, NM Morton, S O'Rahilly, JR Seckl and KE Chapman
J Endocrinol (2007) 194:161-170

Orexin expression is regulated by alpha-melanocyte-stimulating hormone
M López, R Lage, YC Tung, BG Challis, L Varela, S Virtue, S O'Rahilly, A Vidal-Puig, C Diéguez and AP Coll
J Neuroendocrinol (2007) 19:703-707

Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight
B Meister
Physiol Behav (2007) 92:263-271

No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
TD Müller, K Reichwald, AK Wermter, G Brönner, TT Nguyen, S Friedel, K Koberwitz, S Engeli, P Lichtner, T Meitinger, H Schäfer, J Hebebrand and A Hinney
Mol Genet Metab (2007) 90:429-434

Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) defines a subpopulation of hypothalamic POMC neurons
K Dürr, E Norsted, B Gömüc, E Suarez, J Hannibal and B Meister
Brain Res (2007) 1186:203-211

Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens
E Jerlhag, E Egecioglu, SL Dickson, A Douhan, L Svensson and JA Engel
Addict Biol (2007) 12:6-16

Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
S Friedel, K Reichwald, A Scherag, H Brumm, AK Wermter, HR Fries, K Koberwitz, M Wabitsch, T Meitinger, M Platzer, H Biebermann, A Hinney and J Hebebrand
BMC Genet (2007) 8:17

Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
A Hinney, TT Nguyen, A Scherag, S Friedel, G Bronner, TD Muller, H Grallert, T Illig, HE Wichmann, W Rief, H Schafer and J Hebebrand
PLoS ONE (2007) 2:e1361

Circadian and circannual effects on energy balance circuits in the Siberian hamster
JG Mercer, ZA Archer, P Barrett, K Nilaweera, AW Ross and PJ Morgan

Diabesity: Novel molecular targets for obesity and type 2 diabetes
  home | research | publications | members | events | about diabesity | press | links | contact us